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**Modifying DNA to Permanently Cure Diseases**This year has seen some development in health care. The use of DNA modification to totally cure diseases is a notable one. This is an attempt that has proved to be remarkable last year, 2017 as a potential solution to genetic disorder.> Dr sandy Macrae, Sangamo Therapeutics, California stated  ‘We cut your DNA, open it up, insert a gene, stitch it back up. Invisible mending. It becomes part of your DNA and is there for the rest of your life.’Genetic disorders, metabolic diseases such as Hunter syndrome, are the conditions this new discovery can fix. Research says about 10, 000 people or more suffer from Hunter Syndrome all over the world. The number would have doubled or tripled, if not that most patients died while still young. Most did not make it above the age of 10. ‘Many’, Dr Chester Whitley, university of Minnesota said, ‘are in wheel chairs…until they die.’ They have lived their years restricted to chairs, incapable of all human activities and eventually, they die. Some, to fix their health issues, spent each week receiving enzyme treatments. The next week, they must show up. And that does not guarantee a long life.However, tinkering with DNA has brought a new hope. This is an opportunity to rescue thousands of lives which of course include children. The earlier the treatment the better: before it gets worse at adulthood, they can be controlled and treated with this new development. If they are treated at young age, there is chance that they may live longer and the number of people suffering from such gene related diseases will reduce. This is a new method in gene therapy. It is a different from the old popular method of using CRISPR tool. The method is still new and evidence of its effectiveness will only come in months, about four or more precisely. Therefore, patients are to be checked over again to ascertain how effective the treatment has been. It is worthy wait, one that promises to remove pain and restore healthy living and yes, permanently.**Before in the world of gene therapy**Gene therapy is a method of medical care or treatment that involves putting nucleic acid into the cell of a sick person in order to treat diseases. Martin cline, in 1980, was the first to attempt this method of treatment. The first recorded success was in 1989.November last year, 2017 has seen a new development in gene therapy. It is a new different method from the previous popular ones. Why? The attempt is carried out directly in the patient’s body, different from the old method of editing cells in the laboratory. It reduces the stress of returning genes to the patient’s body. It is attempted to treat Hunter syndrome, an incurable and painful disease, and Brian Madeux, a 44-year old patients being the first to undergo such gene editing.  Also, it is different from the previous tools used in editing genes like Crispr-cas9. A different tool named the zinc finger nucleases is used and this works as a typical scissors; it cuts specific DNA.**The process**The treatment is divided into three parts: Two zinc fingers proteins and the new gene. The DNA treatment’s, instructions are installed into a virus that has been changed and safe and that will not infect the patients but will carry the instructions into the patient’s cell. The patient needs up to billions of such DNA commands which the therapists gives it through the veins.They begin their journey to the liver.  There, the cells produce Zinc finger instructions from the instructions and then arrange the genes that would correct the deficiency. The fingers, as expected opens up the DNA, and the new gene is put into it.. Hunter syndrome is a lack of enzyme, therefore the new gene makes cells to create enzymes that are not  in the patient’s body. Job done, but to measure the effectiveness, Doctors might have to wait for months> To summarize it all in the words of Dr Sandy Macrae: ‘We cut your DNA, open it up, insert a gene, and stitch it back up. Invisible mending. It becomes part of your DNA and is there for the rest of your life.’**After the treatment*** **For the patient**It is an attempt to cure disease totally. It sounds good that the disease would be fixed forever. Patients would be relieved of pains that have been a life partner and could have cost their life. Although it takes month to guarantee they have been fully cured, there is hope. Rather than weekly treatment as in the of Hunter syndrome, the patient are rescued permanently.* **For the world of health**A new encouraging development in health care, cells can now be altered in the body of the patients, reducing the time spent in transferring cells altered in the laboratory back to the body. It will be a unique achievement in the field of gene therapy.**Worries associated**Due to past experiences, such as the death of Jesse Gelsinger in a therapy attempt in 1999, some certain worries have been established with this development. One is that new genes, in the environment of other genes, might cause other illness such as leukemia. This is because, in the past, when treating immune system disorder.  new genes intruded and activated cancer gene in existing DNA.Further more, fear and worries point that virus can spread and reach unwanted places like the heart. Also, posting danger for future generations, it could get into egg and sperm.Hank Greely, Stanford University, USA, said, ‘when you stick a chunk of DNA in randomly, sometimes it works well, sometimes it does nothing, and sometimes it causes harm.’It should be noted further that there is no way to correct any blunder this editing of genes may effect. The same reason it works in curing disease permanently. While the fear and worries can not be ruled out, it is important to say if this method of modifying DNA is finally passed as effective after a few months, it would be a good development for patients suffering from genetic disorders.Sources : http://www.independent.co.uk/news/science/dna-permanent-change-cure-disease-experiment-california-brain-madeux-iv-hunter-syndrome-a8055696.htmlhttps://patch.com/california/piedmont/oakland-scientists-attempt-1st-gene-editing-inside-bodyhttp://www.councilchronicle.com/gene-editing-treatment-hunter/27792/https://www.abcactionnews.com/news/health/us-scientists-try-1st-gene-editing-in-the-body-to-change-a-persons-dna-to-cure-a-disease